Catalyst-free arylation of sulfonamides via visible light-mediated deamination

被引：18

作者：

Luo, Yong ^{[1
]}

Ding, Hao ^{[2
]}

Zhen, Jing-Song ^{[1
]}

Du, Xian ^{[1
]}

Xu, Xiao-Hong ^{[1
]}

Yuan, Han ^{[1
]}

Li, Yi-Hui ^{[1
]}

Qi, Wan-Ying ^{[1
]}

Liu, Bing-Zhe ^{[1
]}

Lu, Shi-Man ^{[1
]}

Xue, Can ^{[3
]}

Ding, Qiuping ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Peoples R China

[2] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem Engn & Technol, Zhuhai 519082, Peoples R China

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 27期

基金：

中国国家自然科学基金;

关键词：

SULFUR-DIOXIDE SURROGATE; DIARYL SULFONES; BORONIC ACIDS; SULFONYLATION; ACTIVATION; NITROGEN; CLEAVAGE; AMIDES;

D O I：

10.1039/d1sc02266k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel arylation of sulfonamides with boronic acids to afford numerous diaryl sulfones via a visible light-mediated N-S bond cleavage other than the typical transition-metal-catalyzed C(O)-N bond activation is described. This methodology, which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionalization of diverse sulfonamides indicate the high potential utility of this method in pharmaceutical science and organic synthesis.

引用

页码：9556 / 9560

页数：5

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