Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota

被引：34

作者：

Teruya, T ^{[1
]}

Nakagawa, S ^{[1
]}

Koyama, T ^{[1
]}

Suenaga, K ^{[1
]}

Kita, M ^{[1
]}

Uemura, D ^{[1
]}

机构：

[1] Nagoya Univ, Dept Chem, Grad Sch Sci, Nagoya, Aichi 4648602, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(03)01267-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cytotoxic compound, nakiterpiosin (1), was isolated from the Okinawan sponge Terpios hoshinota. Its structure was determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin showed potent cytotoxicity against P388 cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：5171 / 5173

页数：3

共 49 条

[1] Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota
Teruya, T
Nakagawa, S
Koyama, T
Arimoto, H
Kita, M
Uemura, D
TETRAHEDRON, 2004, 60 (33) : 6989 - 6993
[2] Terpiodiene:: A novel tricyclic alcohol from the Okinawan sponge Terpios hoshinota
Teruya, T
Nakagawa, S
Koyama, T
Suenaga, K
Uemura, D
CHEMISTRY LETTERS, 2002, (01) : 38 - 39
[3] SYNTHESIS OF C-18-FUNCTIONALIZED C-NOR-D-HOMOSTEROID BY HYPOIODITE REACTION
SUGINOME, H
SATO, N
MASAMUNE, T
TETRAHEDRON LETTERS, 1969, (31) : 2671 - &
[4] STEROID HORMONE ANALOGS .2. TRANSFORMATIONS IN C-NOR-D-HOMOSTEROID SERIES
KUPCHAN, SM
MASAMUNE, T
MILNE, GWA
JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (03): : 755 - &
[5] PHOTOINDUCED TRANSFORMATIONS XIII .12. FUNCTIONALIZATION OF 18-METHYL GROUP OF C-NOR-D-HOMOSTEROID BY BARTON REACTION
SUGINOME, H
KOJIMA, T
ORITO, K
MASAMUNE, T
TETRAHEDRON, 1971, 27 (02) : 291 - &
[6] PHOTOINDUCED RADICAL REARRANGEMENTS OF HYPOIODITE OF N-ACETYLJERVINE AND THE RELATED C-NOR-D-HOMOSTEROID IN THE PRESENCE OF MERCURY(II) OXIDE AND IODINE
SUGINOME, H
KATO, K
MASAMUNE, T
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1981, 54 (10) : 3042 - 3047
[7] Novel Cytotoxic Polyoxygenated Steroids from an Okinawan Sponge Dysidea sp.
Govindam, Sudhakar V. S.
Choi, Bong-Keun
Yoshioka, Yukio
Kanamoto, Akihiko
Fujiwara, Takeshi
Okamoto, Tetsuji
Ojika, Makoto
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2012, 76 (05) : 999 - 1002
[8] JASPISAMIDES A-C, NEW CYTOTOXIC MACROLIDES FROM THE OKINAWAN SPONGE JASPIS SP
KOBAYASHI, J
MURATA, O
SHIGEMORI, H
SASAKI, T
JOURNAL OF NATURAL PRODUCTS, 1993, 56 (05): : 787 - 791
[9] Dactyloquinones C, D and E novel sesquiterpenoid quinones, from the Okinawan marine sponge, Dactylospongia elegans
Mitome, H
Nagasawa, T
Miyaoka, H
Yamada, Y
van Soest, RWM
TETRAHEDRON, 2002, 58 (09) : 1693 - 1696
[10] New C-nor,D-homosteroid alkaloid germinine from Veratrum lobelianum
Shakirov R.
Chemistry of Natural Compounds, 1997, 33 (4) : 479 - 480

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