The first total synthesis of dragmacidin D

被引：202

作者：

Garg, NK ^{[1
]}

Sarpong, R ^{[1
]}

Stoltz, BM ^{[1
]}

机构：

[1] CALTECH, Arnold & Mabel Beckham Labs Chem Studies, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 44期

关键词：

D O I：

10.1021/ja027822b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine- and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to the completion of the natural product.

引用

页码：13179 / 13184

页数：6

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