A synergistic combination strategy for optimal inhibition of colon cancer stem cells: Simultaneous inhibition of Insulin-like growth factor-1 receptor-AKT-mammalian target of rapamycin axis and the mevalonate-isoprenoid biosynthetic pathway

被引:0
|
作者
Sharon, Chetna [1 ]
Boothello, Rio [1 ]
Vera, Alberto [1 ]
Patel, Bhaumik B. [1 ]
机构
[1] Massey Canc Ctr, Richmond, VA USA
关键词
D O I
10.1158/1538-7445.AM2019-4667
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4667
引用
收藏
页数:2
相关论文
共 33 条
  • [1] Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo
    Sharon, Chetna
    Baranwal, Somesh
    Patel, Nirmita J.
    Rodriguez-Agudo, Daniel
    Pandak, William M.
    Majumdar, Adhip P. N.
    Krystal, Geoffrey
    Patel, Bhaumik B.
    ONCOTARGET, 2015, 6 (17) : 15332 - 15347
  • [2] If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials
    Vazquez-Martin, Alejandro
    Oliveras-Ferraros, Cristina
    Del Barco, Sonia
    Martin-Castillo, Begona
    Menendez, Javier A.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (33) : E207 - E209
  • [3] If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials Reply
    Goodwin, Pamela J.
    Ligibel, Jennifer A.
    Stambolic, Vuk
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (33) : E210 - E210
  • [4] Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by Rad001
    Baumann, Philipp
    Hagemeier, Hilke
    Mandl-Weber, Sonja
    Franke, Daniel
    Schmidmaier, Ralf
    ANTI-CANCER DRUGS, 2009, 20 (04) : 259 - 266
  • [5] The inhibition of insulin-like growth factor 1 receptor pathway targets putative cancer stem cells in human malignant mesothelioma
    Kim, Yongbaek
    Kai, Kiyonori
    Sills, Robert C.
    FASEB JOURNAL, 2008, 22
  • [6] Inhibition of Insulin-Like Growth Factor Receptor Activity Attenuates Colon Cancer Stem Cells Growth and Self-Renewal by Targeting Mevlonate-Isoprenoid Metabolism
    Sharon, Chetna
    Patel, Jagrut
    Patel, Nirmita J.
    Baranwal, Somesh
    Patel, Bhaumik B.
    GASTROENTEROLOGY, 2014, 146 (05) : S692 - S692
  • [7] Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma
    Desbois-Mouthon, Christele
    Baron, Aurore
    Blivet-Van Eggelpoel, Marie-Jose
    Fartoux, Laetitia
    Venot, Corinne
    Bladt, Friedhelm
    Housset, Chantal
    Rosmorduc, Olivier
    CLINICAL CANCER RESEARCH, 2009, 15 (17) : 5445 - 5456
  • [8] Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways
    Tamburini, Jerome
    Chapuis, Nicolas
    Bardet, Valrie
    Park, Sophie
    Sujobert, Pierre
    Willems, Lise
    Ifrah, Norbert
    Dreyfus, Francois
    Mayeux, Patrick
    Lacombe, Catherine
    Bouscary, Didier
    BLOOD, 2008, 111 (01) : 379 - 382
  • [9] Targeting Non-Small Cell Lung Cancer Cells by Dual Inhibition of the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor
    Vincent, Emma E.
    Elder, Douglas J. E.
    Curwen, Jon
    Kilgour, Elaine
    Hers, Ingeborg
    Tavare, Jeremy M.
    PLOS ONE, 2013, 8 (06):
  • [10] Insulin-like growth factor-1 (IGF-1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway
    Han, Bing
    Tong, Junfeng
    Zhu, Mei J.
    Ma, Changwei
    Du, Min
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 2008, 75 (05) : 810 - 817