RhI-Catalyzed Intramolecular [3+2] Cycloaddition of 1-Allene-vinylcyclopropanes

被引：7
|
作者：
Liu, Cheng-Hang [1 ]
Li, Feng [1 ]
Yuan, Yuan [1 ]
Dou, Meng [1 ]
Yu, Zhi-Xiang [1 ]
机构：
[1] Peking Univ, Coll Chem, Minist Educ, BNLMS,Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 08期
基金：
中国国家自然科学基金;
关键词：
allenes; bicyclic compounds; cycloaddition; rhodium; vinylcyclopropanes; RH(I)-CATALYZED (3+2)+1 CYCLOADDITION; AMINO-SUBSTITUTED CYCLOPROPANES; BOND ACTIVATION; ENE-VINYLCYCLOPROPANES; 8-MEMBERED CARBOCYCLES; VINYL AZIRIDINES; FORMAL SYNTHESIS; ALKYNES; CO; METHYLENECYCLOPROPANES;
D O I：
10.1002/ajoc.201800294
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium-catalyzed intramolecular [3+2] cycloaddition of 1-allene-vinylcyclopropanes (1-allene-VCPs) to construct cyclopentane-embedded bicyclic structures with quaternary stereocenters at the bridgehead position has been developed with good to excellent yields. In addition, this transformation could also be conducted on a large scale with reduced catalyst loading, which could be useful for further derivatizations and applications.
引用
收藏
页码：1609 / 1613
页数：5
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