Specific HLA alleles, paired with TCR V- and J-gene segment usage, link to distinct multiple myeloma survival rates

被引:7
|
作者
Huda, Taha I. [1 ]
Mihyu, Moody [1 ]
Gozlan, Etienne C. [1 ]
Arndt, Mary F. [1 ]
Diaz, Michael J. [1 ]
Zaman, Saif [1 ]
Chobrutskiy, Boris I. [1 ]
Blanck, George [1 ,2 ]
机构
[1] Univ S Florida, Dept Mol Med, Morsani Coll Med, 12901 Bruce B Downs Bd MDC7, Tampa, FL 33612 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL USA
关键词
Multiple myeloma; T-cell receptor recombination reads; survival rates; HLA; blood sample exomes; CELL-RECEPTOR V; T-CELLS; EXPRESSION; IMMUNE;
D O I
10.1080/10428194.2021.1885655
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Multiple myeloma (MM) immunogenomics studies related to T-cell characterizations and involving large patient sets have been lacking, particularly in comparison to solid tumor types. Thus, we evaluated (i) HLA alleles, and (ii) T-Cell Receptor (TCR) V- and J-gene segment, HLA allele combinations, based on TCR recombinations in blood samples, for their potential associations with overall survival distinctions among an MM cohort. Two HLA alleles, and seven TCR V- or J-gene segment, HLA allele combinations were found to be associated with distinct overall survival rates. For examples, HLA-C*08:02, and the TRAV19, HLA-C*07:01 combination, were found to be associated with negative outcomes. In addition, anti-cytomegalovirus immune receptor sequences, from blood samples, were found to be associated with a positive outcome (p = 0.012, n = 278). These data, and other related immunogenomics data, indicate a potential opportunity to use personal immunogenetics parameters as guides to prognosis and therapies.
引用
收藏
页码:1711 / 1720
页数:10
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