Protein targeting from malaria parasites to host erythrocytes

被引：14
|
作者：
Römisch, K
机构：
[1] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 2XY, England
[2] Univ Cambridge, Dept Clin Biochem, Cambridge CB2 2XY, England
来源：
TRAFFIC | 2005年 / 6卷 / 08期
基金：
英国惠康基金;
关键词：
malaria; membrane integration; protein trafficking; protein translocation across membranes; red blood cell; targeting signals;
D O I：
10.1111/j.1600-0854.2005.00310.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Malaria is caused by obligate intracellular parasites, which live in host erythrocytes and remodel these cells to provide optimally for their own needs. Plasmodium falciparum, responsible for malaria in humans, transports many proteins into erythrocytes which help the parasite survive in the host. The recent discovery of a host cell-targeting sequence present in both soluble and transmembrane P. falciparum proteins provoked a discussion on the potential mechanisms of parasite protein entry into infected erythrocytes which is summarized here.
引用
收藏
页码：706 / 709
页数：4
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