Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer's Disease-Related Pathology

被引：57
|
作者：
Michaud, Jean-Philippe [1 ]
Rivest, Serge [1 ]
机构：
[1] Univ Laval, Dept Mol Med, Fac Med, Neurosci Lab,CHU Quebec Res Ctr, Quebec City, PQ G1V 4G2, Canada
来源：
NEURON | 2015年 / 85卷 / 03期
基金：
加拿大健康研究院;
关键词：
AMYLOID DEPOSITION; BETA; PHAGOCYTOSIS; REVEALS;
D O I：
10.1016/j.neuron.2015.01.021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits A beta clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an innate immune defense mechanism in AD.
引用
收藏
页码：450 / 452
页数：3
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