Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

被引：25
|
作者：
Dorr, Casey R. [1 ]
Yemets, Sergiy [2 ]
Kolomitsyna, Oksana [2 ]
Krasutsky, Pavel [2 ]
Mansky, Louis M. [1 ]
机构：
[1] Univ Minnesota, Inst Mol Virol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期
关键词：
Retrovirus; Antiviral; Antiretroviral; Proteolysis; Protease; BETULINIC ACID; HIV-1; MATURATION; RESISTANCE; BEVIRIMAT; PA-457; STEP;
D O I：
10.1016/j.bmcl.2010.10.078
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：542 / 545
页数：4
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