Patterns of brain activation in patients with mild Alzheimer's disease during performance of subtraction - An fMRI study

被引：4
|
作者：
Xie, S [1 ]
Xiao, JX [1 ]
Bai, J [1 ]
Jiang, XX [1 ]
机构：
[1] Peking Univ, Dept Radiol, Hosp 1, Beijing 100034, Peoples R China
来源：
CLINICAL IMAGING | 2005年 / 29卷 / 02期
关键词：
functional MRI; Alzheimer's disease; arithmetic;
D O I：
10.1016/j.clinimag.2004.03.022
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
We performed a functional MRI (fMRI) study to compare the difference of activation between healthy aged people and patients with mild Alzheimer's disease (AD) during performance of subtraction. Nine patients with mild AD and nine healthy aged volunteers were recruited in this study. The analysis of fMRI data revealed that brain activation is decreased in several regions in AD patients in comparison with healthy participants. But in the right inferior prefrontal lobe, activation is greater in patients than in the controls. We believe that our findings will help the understanding mechanism of neuronal activity in AD. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：94 / 97
页数：4
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