Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects

被引：77

作者：

Yang, Taowei ^{[1
,2
]}

Rao, Zhiming ^{[1
,2
]}

Zhang, Xian ^{[1
]}

Xu, Meijuan ^{[1
]}

Xu, Zhenghong ^{[3
]}

Yang, Shang-Tian ^{[4
]}

机构：

[1] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Peoples R China

[2] Jiangnan Univ, Rugao Food Biotechnol Res Inst, Rugao, Jiangsu, Peoples R China

[3] Jiangnan Univ, Sch Pharmaceut Sci, Lab Pharmaceut Engn, Wuxi, Peoples R China

[4] Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43210 USA

来源：

CRITICAL REVIEWS IN BIOTECHNOLOGY | 2017年 / 37卷 / 08期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Strain improvement; 2,3-butanediol dehydrogenase; regulation mechanism; biotechnological production; cofactor engineering; low-cost substrate; gene knockout; construction; THERMOPHILIC BACILLUS-LICHENIFORMIS; HIGH-YIELD PRODUCTION; BIODIESEL-DERIVED GLYCEROL; ESCHERICHIA-COLI; KLEBSIELLA-OXYTOCA; SERRATIA-MARCESCENS; MOLECULAR CHARACTERIZATION; MICROBIAL-PRODUCTION; EFFICIENT PRODUCTION; GENOME SEQUENCE;

D O I：

10.1080/07388551.2017.1299680

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology.

引用

页码：990 / 1005

页数：16

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