Chronic valproic acid intoxication: reversal by naloxone

被引：8
|
作者：
Thanacoody, H. K. R.
机构：
[1] Scottish Poisons Information Bureau, Royal Infirmary Edinburgh, Edinburgh
来源：
EMERGENCY MEDICINE JOURNAL | 2007年 / 24卷 / 09期
关键词：
D O I：
10.1136/emj.2007.049791
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4 day history of acute confusion and tremulousness. She had apnoeic episodes, reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 mu mol/l ( normal 300-600 mu mol/l). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.
引用
收藏
页码：677 / 678
页数：2
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