A new electrochemical modified graphite pencil electrode developed for cholesterol assessing

In this regard, a new sensitive electrochemical sensor has been introduced for direct detection of cholesterol (CHL). The proposed sensor was manufactured by modifying the pencil graphite electrode (PGE) with copper nanoparticles (CuNPs) and indole (IND). The chemical modifiers of CuNPs and IND were easily deposited on PGE via electrodeposition procedure. The designed sensor exhibited a desired catalytic response to CHL with the archived parameters of alpha = 0.62, log Ks = 3.42 and Gamma = 2. 74 x 10(-8) in the optimized pH of 7. The morphology of the constructed films was characterized by scanning electron microscopy technique. For this sensor, a linear calibration curve is plotted within the range of 15-195 nmolL(-1), and the limit of detection was achieved 4.98 nmolL(-1). Furthermore, the offered sensor was employed to direct measuring of CHL in human serums, and the acceptable accuracies were acquired for this method without any side interferences.