Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents

被引：40

作者：

Zheng, Qing-Zhong ^{[1
]}

Cheng, Kui ^{[1
]}

Zhang, Xiao-Min ^{[1
]}

Liu, Kai ^{[1
]}

Jiao, Qing-Cai ^{[1
]}

Zhu, Hai-Liang ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 07期

基金：

美国国家科学基金会;

关键词：

Urea derivatives; Synthesis; Antibacterial; Antifungal; CARBONYLATION; ISOCYANATES; INHIBITORS; AMINES;

D O I：

10.1016/j.ejmech.2010.03.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3207 / 3212

页数：6

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