TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases

被引：48
|
作者：
Hiew, Lih-Fhung [1 ]
Poon, Chi-Him [1 ]
You, Heng-Ze [1 ]
Lim, Lee-Wei [1 ]
机构：
[1] Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Fac Med, Neuromodulat Lab, Hong Kong, Peoples R China
来源：
CELLS | 2021年 / 10卷 / 06期
关键词：
neurogenesis; TGF-beta; smad; depression; stress; GROWTH-FACTOR-BETA; ELEMENT-BINDING PROTEIN; ADULT HIPPOCAMPAL NEUROGENESIS; CHRONIC PSYCHOSOCIAL STRESS; CAMP RESPONSE; DENTATE GYRUS; CELL-PROLIFERATION; ANTIDEPRESSANT TREATMENT; FUNCTIONAL CONNECTIVITY; NEURONAL-ACTIVITY;
D O I：
10.3390/cells10061382
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TGF-beta/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF-beta/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF-beta/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-beta/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF-beta/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.
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页数：17
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