Analysis of molecular forms of albumin in urine

被引：13
|
作者：
Hortin, Glen L. [1 ]
Sviridov, Denis [1 ]
机构：
[1] NIH, Dept Lab Med, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA
来源：
PROTEOMICS CLINICAL APPLICATIONS | 2008年 / 2卷 / 7-8期
关键词：
albuminuria; kidney disease; urinary albumin; urinary peptidomics; urinary proteomics;
D O I：
10.1002/prca.200780145
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Albumin is not only one of the most abundant urinary protein components and one of the most widely used clinical markers for kidney disease, it also is a significant source of molecular complexity of the urinary proteome and peptidome. Urine contains multiple fragments and modified forms of albumin. Analysis of molecular forms of albumin in urine is of fundamental importance for understanding clinical assays for albumin quantification, specimen stability, and proteomic and peptidomic analysis of urine.
引用
收藏
页码：950 / 955
页数：6
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