The changing epidemiology of hepatocellular carcinoma in Greece

被引:6
|
作者
Markakis, George E. [1 ]
Koulouris, Andreas [2 ]
Tampaki, Maria [1 ]
Cholongitas, Evangelos [3 ]
Deutsch, Melanie [4 ]
Papatheodoridis, George V. [1 ]
Koskinas, John [4 ]
机构
[1] Natl & Kapodistrian Univ Athens, Dept Gastroenterol, Med Sch, Athens, Greece
[2] Univ Crete, Med Sch, Dept Oncol, Iraklion, Greece
[3] Natl & Kapodistrian Univ Athens, Dept Internal Med 1, Med Sch, Athens, Greece
[4] Natl & Kapodistrian Univ Athens, Med Sch, Dept Internal Med 2, Athens, Greece
来源
ANNALS OF GASTROENTEROLOGY | 2022年 / 35卷 / 01期
关键词
Hepatocellular carcinoma; liver; cancer; epidemiology; HEPATITIS-C VIRUS; RISK-FACTORS; INFECTION; ETIOLOGY; DISEASE; HEPNET; BURDEN; HCV;
D O I
10.20524/aog.2021.0680
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Hepatocellular carcinoma (HCC) is the sixth most common cancer globally, and is attributable mainly to viral hepatitis, alcohol and nonalcoholic fatty liver disease. Methods Three hundred Greek patients diagnosed with HCC between 2000 and 2019 were retrospectively evaluated for patient and HCC characteristics. Patients were classified as before 2011 (A) or after 2011 (B) and HCC risk factors were compared with historic Greek cohorts. Results The median age was 64 years and 86% were male; 45% had chronic hepatitis B virus (HBV) infection, 26% chronic hepatitis C virus (HCV) infection, and 30% non-viral liver diseases (nvLD). No change was observed among liver diseases between periods A and B. However, there was a trend towards a decrease in virally and an increase in non-virally induced HCC (P=0.075). Patients in period B (vs. A) were more likely to be diagnosed with fewer (<3, P=0.006) and smaller (<3 cm, P=0.005) nodules. Compared with 1558 Greek HCC patients from 1974-2000, there was a decrease in HBV and an increase in HCV and nvLD-related HCCs (P<0.001). Conclusions In Greece, after 2000, there was a decrease in the proportion of HBV and an increase in the proportion of HCV and nvLD-related HCC, while over the last 2 decades there has been a trend towards a decrease in virally and an increase in non-virally induced HCC. Since 2011, HCC is being diagnosed at an earlier stage, possibly reflecting improved surveillance strategies.
引用
收藏
页码:88 / 94
页数:7
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