Results from a Phase 3, Multicenter, Non-Inferiority Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Currently Treated with Eculizumab

被引：0

作者：

Kulasekararaj, Austin G. ^{[1
]}

Hill, Anita ^{[2
]}

Rottinghaus, Scott T. ^{[3
]}

Langemeijer, Saskia ^{[4
]}

Wells, Richard A. ^{[5
]}

Gonzalez-Fernandez, F. Ataulfo ^{[6
]}

Gaya, Anna ^{[7
]}

Lee, Jong-Wook ^{[8
]}

Gutierrez, Emilio Ojeda ^{[9
]}

Piatek, Caroline I. ^{[10
]}

Szer, Jeffrey ^{[11
]}

Risitano, Antonio M. ^{[12
]}

Nakao, Shinji ^{[13
]}

Bachman, Eric ^{[3
]}

Shafner, Lori ^{[3
]}

Damokosh, Andrew I. ^{[3
]}

Ortiz, Stephan ^{[3
]}

Roeth, Alexander ^{[14
]}

De latour, Regis Peffault ^{[15
]}

机构：

[1] Kings Coll Hosp London, Dept Haematol, London, England

[2] Leeds Teaching Hosp, Dept Haematol, Leeds, W Yorkshire, England

[3] Alex Pharmaceut Inc, New Haven, CT USA

[4] Radboudumc, Nijmegen, Netherlands

[5] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[6] Hosp Univ Clin San Carlos, San Carlos, Spain

[7] Hosp Clin Barcelona, Barcelona, Spain

[8] Catholic Univ Korea, Seoul St Marys Hosp, Dept Hematol, Seoul, South Korea

[9] Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain

[10] Univ Southern Calif, Keck Sch Med, Jane Anne Nohl Div Hematol, Los Angeles, CA USA

[11] Royal Melbourne Hosp, Clin Haematol, Melbourne, Vic, Australia

[12] Univ Naples Federico II, Dept Clin Med & Surg, Hematol, Naples, Italy

[13] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Fac Med, Haematol Resp Med, Kanazawa, Ishikawa, Japan

[14] Univ Hosp Essen, West German Canc Ctr, Dept Hematol, Essen, Germany

[15] St Louis Hosp, AP HP, Bone Marrow Transplantat BMT Unit, Paris, France

来源：

BLOOD | 2018年 / 132卷

关键词：

D O I：

10.1182/blood-2018-99-119147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

625

引用

页数：4

共 50 条

[1] A phase 3 study of Ravulizumab (ALXN1210) vs. Eculizumab in adults with paroxysmal nocturnal hemoglobinuria currently treated with Eculizumab: subgroup analysis by transfusion history and demographics
Risitano, A.
Roeth, A.
Hill, A.
Charbonnier, A.
Schouten, H. C.
Khaled, S.
Gutierrez, E. O.
Ogawa, M.
Yu, J.
Rottinghaus, S.
Ishiyama, K.
Kulasekararaj, A.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2019, 42 : 302 - 302
[2] Results from multinational phase 3 studies of ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria: subgroup analysis of Japanese patients
Ishiyama, Ken
Nakao, Shinji
Usuki, Kensuke
Yonemura, Yuji
Ikezoe, Takayuki
Uchiyama, Michihiro
Mori, Yasuo
Fukuda, Tetsuya
Okada, Masaya
Fujiwara, Shin-ichiro
Noji, Hideyoshi
Rottinghaus, Scott
Aguzzi, Rasha
Yokosawa, Jun
Nishimura, Jun-Ichi
Kanakura, Yuzuru
Okamoto, Shinichiro
[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2020, 112 (04) : 466 - 476
[3] Results from a phase 3, multicenter, noninferiority study of ravulizumab (ALXN1210) versus eculizumab (ECU) in adult patients (PTS) with paroxysmal nocturnal hemoglobinuria (PNH) naive to complement inhibitors (CI)
Schrezenmeier, H.
Lee, J. W.
Rottinghaus, S. T.
Lee, Lee L. W.
Pessoa, V.
Gualandro, S.
Fuereder, W.
Ptushkin, V.
de Fontbrune, Sicre F.
Volles, L.
Shafner, L.
Damokosh, A. I.
Aguzzi, R.
Pradhan, R.
Ortiz, S.
Hill, A.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 332 - +
[4] Results from multinational phase 3 studies of ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria: subgroup analysis of Japanese patients
Ken Ishiyama
Shinji Nakao
Kensuke Usuki
Yuji Yonemura
Takayuki Ikezoe
Michihiro Uchiyama
Yasuo Mori
Tetsuya Fukuda
Masaya Okada
Shin-ichiro Fujiwara
Hideyoshi Noji
Scott Rottinghaus
Rasha Aguzzi
Jun Yokosawa
Jun-Ichi Nishimura
Yuzuru Kanakura
Shinichiro Okamoto
[J]. International Journal of Hematology, 2020, 112 : 466 - 476
[5] Ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria: pharmacokinetics and pharmacodynamics observed in two Phase 3 randomized, multicenter studies
De Latour, R. Peffault
Mitchell, L.
Brodsky, R. A.
Ortiz, S.
Risitano, A. M.
Jang, J. -H.
Hillmen, P.
Kulagin, A. D.
Pradhan, R.
Rottinghaus, S. T.
Aguzzi, R.
Wells, R. A.
Szer, J.
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2019, 185 : 110 - 110
[6] Ravulizumab (ALXN1210) Versus Eculizumab in Adults with Paroxysmal Nocturnal Hemoglobinuria: Pharmacokinetics and Pharmacodynamics Observed in Two Phase 3 Randomized, Multicenter Studies
De Latour, Regis Peffault
Brodsky, Robert A.
Ortiz, Stephan
Risitano, Antonio M.
Jang, Jun-Ho
Hillmen, Peter
Kulagin, Aleksandr
Pradhan, Rajendra
Rottinghaus, Scott T.
Aguzzi, Rasha
Wells, Richard A.
Szer, Jeffrey
[J]. BLOOD, 2018, 132
[7] Patient preferences for the treatment of paroxysmal nocturnal hemoglobinuria: results of a patient survey of ravulizumab (ALXN1210) and eculizumab in the UK
Peipert, J. Devin
Griffin, M.
Kulasekararaj, A.
Yount, S.
Martens, C.
Sparling, A.
Webster, K. A.
Cella, D.
Tomazos, I.
Ogawa, M.
Yu, J.
Hill, A.
Kaiser, K.
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2020, 189 : 143 - 144
[8] Transfusion requirements in adult patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibitors receiving Ravulizumab or Eculizumab: results from a phase 3 non-inferiority study
Roeth, A.
Risitano, A.
Jang, J. H.
Lee, G. -W.
Wanachiwanawin, W.
Schrezenmeier, H.
Yonemura, Y.
Munir, T.
Pavani, R.
Aguzzi, R.
Shafner, L.
Kulagin, A.
de Fontbrune, Sicre F.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2019, 42 : 97 - 97
[9] A Phase 3 Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adults with Paroxysmal Nocturnal Hemoglobinuria Naive to Complement Inhibitors: Results of a Subgroup Analysis with Patients Stratified By Baseline Hemolysis Level, Transfusion History, and Demographics
Weitz, Ilene C.
Kulagin, Aleksandr
Nakao, Shinji
Piatek, Caroline I.
Szer, Jeffrey
Rottinghaus, Scott T.
Volles, Lori
Damokosh, Andrew I.
Aguzzi, Rasha
Larratt, Loree
Risitano, Antonio M.
[J]. BLOOD, 2018, 132
[10] A prospective analysis of breakthrough haemolysis in two Phase 3 randomised studies of ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal haemoglobinuria
Brodsky, R. A.
Hill, A.
De Latour, R. Peffault
Rottinghaus, S. T.
Roeth, A.
Risitano, A. M.
Weitz, I. C.
Hillmen, P.
Maciejewski, J. P.
Szer, J.
Lee, J. -W.
Kulasekararaj, A. G.
Volles, L.
Damokosh, A. I.
Ortiz, S.
Shafner, L.
Schrezenmeier, H.
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2019, 185 : 111 - 112

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