Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats

被引：27

作者：

Can, Ozgur Devrim ^{[1
]}

Ozturk, Yusuf ^{[1
]}

Ozturk, Nilgun ^{[2
]}

Sagratini, Gianni ^{[3
]}

Ricciutelli, Massimo ^{[3
]}

Vittori, Sauro ^{[3
]}

Maggi, Filippo ^{[3
]}

机构：

[1] Anadolu Univ, Dept Pharmacol, Fac Pharm, TR-26470 Eskisehir, Turkey

[2] Anadolu Univ, Dept Pharmacognosy, Fac Pharm, TR-26470 Eskisehir, Turkey

[3] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy

来源：

FITOTERAPIA | 2011年 / 82卷 / 04期

关键词：

St. John's Wort; Hypericum perforatum; Diabetes mellitus; Rutin; Tail pinch; Tail flick; NEUROPATHIC PAIN; IN-VITRO; MECHANICAL HYPERALGESIA; MEDIATED INHIBITION; RUTIN; NEURONS; ANTIOXIDANT; ALLODYNIA; BEHAVIOR; EXTRACT;

D O I：

10.1016/j.fitote.2011.01.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：576 / 584

页数：9

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