Advances in Treatment of Locally Advanced or Metastatic Non-Small Cell Lung Cancer: Targeted Therapy

被引：18

作者：

Giustini, Nicholas P. ^{[1
]}

Jeong, Ah-Reum ^{[1
]}

Buturla, James ^{[1
]}

Bazhenova, Lyudmila ^{[1
]}

机构：

[1] UCSD Moores Canc Ctr, 3855 Hlth Sci Dr MC 0987, La Jolla, CA 92093 USA

来源：

CLINICS IN CHEST MEDICINE | 2020年 / 41卷 / 02期

关键词：

Lung cancer; Non-small cell lung cancer (NSCLC); Tyrosine kinase inhibitor (TKI); Targeted therapy; EGFR; ALK; ROS1; NTRK; BRAF; PHASE-II TRIAL; DABRAFENIB PLUS TRAMETINIB; OPEN-LABEL; RET PROTOONCOGENE; CLINICAL ACTIVITY; EGFR MUTATION; SINGLE-ARM; CRIZOTINIB; ROS1; MET;

D O I：

10.1016/j.ccm.2020.02.003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The treatment of metastatic non-small cell lung cancer (NSCLC) is constantly evolving. Although the advent of immunotherapy has played an important role in the treatment of patients with NSCLC, the identification of driver mutations and the subsequent specific treatment of these targets often lead to durable responses while maintaining quality of life. This review delves into targeted therapies available for epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, neurotrophic tropomyosin receptor kinase, and BRAF mutated NSCLC patients, as well as other mutations with promising novel drugs under clinical investigation.

引用

页码：223 / +

页数：14

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