Complete Genome Sequence of an Overattenuated Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

被引：7

作者：

Wu, Jiajun ^{[1
]}

Chen, Nanhua ^{[1
,2
]}

Han, Wei ^{[1
]}

Cao, Zhen ^{[1
]}

Deng, Xiaoyu ^{[1
]}

Wang, Lilin ^{[1
]}

Yu, Xiuling ^{[1
]}

Zhou, Zhi ^{[1
]}

Li, Xiangdong ^{[2
]}

Shi, Jishu ^{[2
]}

Tian, Kegong ^{[1
]}

机构：

[1] China Anim Dis Control Ctr, Vet Diagnost Lab, Beijing, Peoples R China

[2] Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, Manhattan, KS 66506 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 11期

关键词：

CHINA; EMERGENCE; VARIANTS; PRRS;

D O I：

10.1128/JVI.00710-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV.

引用

页码：6381 / 6382

页数：2

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