Advances in research of apolipoprotein E and Alzheimer's disease

被引：0
|
作者：
Liu Qian [1 ]
Wu Weihui [1 ]
Li Renwang [1 ]
Zheng Yizhe [1 ]
Zhao Yufen [1 ]
Li Yanmei [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
来源：
PROGRESS IN CHEMISTRY | 2007年 / 19卷 / 12期
关键词：
Alzheimer's disease; apolipoprotein e; beta-amyloid plaque; Tau;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The apolipoprotein E(ApoE) type 4 allele(ApoE4) is a highly susceptive gene for late-onset familial and sporadic Alzheimer's disease. Both the major pathologic hallmarks beta-amyloid plaque and neurofibrilary tangles(NFTs) are related to ApoE, of which the main function in Alzheimer' s disease and the recent advances in potential related drugs domestic and abroad are discussed.
引用
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页码：2006 / 2011
页数：6
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