Precision medicine in COPD: where are we and where do we need to go?

被引:59
|
作者
Sidhaye, Venkataramana K. [1 ,2 ]
Nishida, Kristine [1 ]
Martinez, Fernando J. [3 ]
机构
[1] Johns Hopkins Sch Med, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD USA
[2] Johns Hopkins Sch Publ Hlth, Dept Environm Hlth & Engn, Baltimore, MD USA
[3] Univ Michigan Hlth Syst, Dept Med, Div Pulm & Crit Care Med, Ann Arbor, MI USA
来源
EUROPEAN RESPIRATORY REVIEW | 2018年 / 27卷 / 149期
基金
美国国家卫生研究院;
关键词
OBSTRUCTIVE PULMONARY-DISEASE; LUNG-FUNCTION TRAJECTORIES; BLOOD EOSINOPHIL COUNT; POST-HOC ANALYSIS; OVERLAP SYNDROME; GLOBAL STRATEGY; DOUBLE-BLIND; ALPHA-1-ANTITRYPSIN DEFICIENCY; CORTICOSTEROID TREATMENT; INHALED CORTICOSTEROIDS;
D O I
10.1183/16000617.0022-2018
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD. It is possible that multiOMICs can be used as a tool to integrate data from multiple fields. Moreover, analysis of electronic medical records could aid in the treatment of patients and in the predictions of outcomes. The Precision Medicine Initiative created in 2015 has made precision medicine approaches to treat disease a reality; one of these diseases being COPD.
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页数:15
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