Stem cell differentiation: Cardiac repair

被引：18
|
作者：
Rubart, Michael [1 ,2 ]
Field, Loren J. [1 ,2 ]
机构：
[1] Indiana Univ, Sch Med, Herman B Wells Ctr Pediat Res, Div Pediat Cardiol, Indianapolis, IN USA
[2] Indiana Univ, Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA
来源：
CELLS TISSUES ORGANS | 2008年 / 188卷 / 1-2期
关键词：
cardiac regeneration; cell transplantation; clinical studies ~; heart disease;
D O I：
10.1159/000112846
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Cellular transplantation has been employed for several years to deliver donor cardiomyocytes to normal and injured hearts. Recent reports of a variety of stem cells with apparent cardiomyogenic potential have raised the possibility of cell transplantation-based therapeutic interventions for heart disease. Here we review the preclinical studies demonstrating that intracardiac transplantation of skeletal myoblasts, cardiomyocytes and cardiomyogenic stem cells is feasible. In addition, recent clinical studies of skeletal myoblast and adult stem cell transplantation for heart disease are discussed. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码：202 / 211
页数：10
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