An ontology-based fuzzy decision support system for multiple sclerosis

The use of Magnetic Resonance (MR) as a supporting tool in the diagnosis and monitoring of multiple sclerosis (MS) and in the assessment of treatment effects requires the accurate determination of cerebral white matter lesion (WML) volumes. In order to automatically support neuroradiologists in the classification of WMLs, an ontology-based fuzzy decision support system (DSS) has been devised and implemented. The DSS encodes high-level, specialized medical knowledge in terms of ontologies and fuzzy rules and applies this knowledge in conjunction with a fuzzy inference engine to classify WMLs and to obtain a measure of their volumes. The performance of the DSS has been quantitatively evaluated on 120 patients affected by MS. Specifically, binary classification results have been first obtained by applying thresholds on fuzzy outputs and then evaluated, by means of ROC curves, in terms of trade-off between sensitivity and specificity. Similarity measures of WMLs have been also computed for a further quantitative analysis. Moreover, a statistical analysis has been carried out for appraising the DSS influence on the diagnostic tasks of physicians. The evaluation has shown that the DSS offers an innovative and valuable way to perform automated WML classification in real clinical settings. (C) 2011 Elsevier Ltd. All rights reserved.