Adjuvant Imatinib Therapy for Gastrointestinal Stromal Tumors

被引：6
|
作者：
Pisters, Peter W. T. [1 ,2 ]
Colombo, Chiara [1 ,2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Sarcoma Res Ctr, Houston, TX 77030 USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 104卷 / 08期
关键词：
imatinib; adjuvant therapy; GIST; gastrointestinal stromal tumor; risk stratification; adverse events; ESMO CLINICAL RECOMMENDATIONS; KINASE INHIBITOR STI571; OF-FUNCTION MUTATIONS; ABL TYROSINE KINASE; EORTC SOFT-TISSUE; SARCOMA GROUP; PHASE-III; C-KIT; MESYLATE; RESISTANCE;
D O I：
10.1002/jso.22002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Surgery is the standard of care for primary resectable gastrointestinal stromal tumors (GISTs), but half of surgically treated patients relapse. Imatinib (IM) has been shown to prolong recurrence-free survival after complete surgery and is now approved as adjuvant therapy (400 mg/day) for high-risk GIST patients. IM is well tolerated, with mild to moderate side effects observed. Whether adjuvant IM prolongs overall survival is under evaluation in two ongoing clinical trials. J. Surg. Oncol. 2011;104:896-900. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码：896 / 900
页数：5
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