The Anti-CD38 Monoclonal Antibody TAK-079 Depletes Antibody Secreting Cells from Normal and SLE Patients

被引:0
|
作者
Wang, Xiaoqian [1 ,2 ]
Dahl, Martin [3 ]
Nguyen, Doan [4 ]
Jenks, Scott [1 ,2 ]
Cashman, Kevin [1 ,2 ]
Lee, F. Eun-Hyung [5 ]
McLean, Lachy [6 ]
Sanz, Ignacio [2 ,7 ]
机构
[1] Emory Univ, Sch Med, Div Rheumatol, Atlanta, GA USA
[2] Emory Univ, Sch Med, Lowance Ctr Human Immunol, Atlanta, GA USA
[3] Tekada Pharmaceut, San Diego, CA USA
[4] Emory Univ, Sch Med, Atlanta, GA USA
[5] Emory Univ, Sch Med, Med, Atlanta, GA USA
[6] Takeda Global Res & Dev Ctr Inc, San Diego, CA USA
[7] Emory Univ, Sch Med, Rheumatol, Atlanta, GA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1085
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Safety, tolerability, pharmacokinetics and pharmacodynamics of the anti-CD38 cytolytic antibody TAK-079 in healthy subjects
    Fedyk, Eric R.
    Zhao, Lin
    Koch, Annelize
    Smithson, Glennda
    Estevam, Jose
    Chen, Grace
    Lahu, Gezim
    Roepcke, Stefan
    Lin, Jianchang
    Mclean, Lachy
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020, 86 (07) : 1314 - 1325
  • [2] Pharmacokinetics and pharmacodynamics of the cytolytic anti-CD38 human monoclonal antibody TAK-079 in monkey - model assisted preparation for the first in human trial
    Roepcke, Stefan
    Plock, Nele
    Yuan, Josh
    Fedyk, Eric R.
    Lahu, Gezim
    Zhao, Lin
    Smithson, Glennda
    PHARMACOLOGY RESEARCH & PERSPECTIVES, 2018, 6 (03):
  • [3] TAK-079 is a high affinity monoclonal antibody that effectively mediates CD38+cell depletion
    Smithson, Glennda
    Zalevsky, Jonathan
    Korver, Wouter
    Roepcke, Stefan
    Dahl, Martin
    Zhao, Lin
    Yuan, Josh
    McLean, Lachy
    Elias, Kathleen
    JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
  • [4] A phase Ib study of TAK-079, an investigational anti-CD38 monoclonal antibody (mAb) in patients with relapsed/ refractory multiple myeloma (RRMM): Preliminary results.
    Krishnan, Amrita Y.
    Patel, Krina K.
    Hari, Parameswaran
    Jagannath, Sundar
    Niesvizky, Ruben
    Silbermann, Rebecca Wang
    Berg, Deborah T.
    Li, Qing
    Allikmets, Kristina
    Stockerl-Goldstein, Keith
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [5] Preliminary Results from a Phase 1b Study of TAK-079, an Investigational Anti-CD38 Monoclonal Antibody (mAb) in Patients with Relapsed/ Refractory Multiple Myeloma (RRMM)
    Krishnan, Amrita Y.
    Patel, Krina K.
    Hari, Parameswaran
    Jagannath, Sundar
    Niesvizky, Ruben
    Silbermann, Rebecca W.
    Berg, Deborah
    Lin, Jianchang
    Fedyk, Eric Robert
    Palumbo, Antonio
    Stockerl-Goldstein, Keith E.
    BLOOD, 2019, 134
  • [6] Transfusion management for patients taking an anti-CD38 monoclonal antibody
    Bub, Carolina Bonet
    dos Reis, Isabel Nagle
    Aravechia, Maria Giselda
    Santos, Leandro Dinalli
    Bastos, Eduardo Peres
    Kutner, Jose Mauro
    Castilho, Lilian
    HEMATOLOGY TRANSFUSION AND CELL THERAPY, 2018, 40 (01) : 25 - 29
  • [7] A Single Administration of the Cytolytic CD38 Antibody TAK-079 to Healthy Subjects: Tolerability, Pharmacokinetics and Pharmacodynamics
    Fedyk, Eric Robert
    Berg, Deborah
    Smithson, Glenda
    Estevam, Jose
    Mclean, Lachy
    Allikmets, Kristina
    Palumbo, Antonio
    BLOOD, 2018, 132
  • [8] Therapeutic Anti-CD38 Monoclonal Antibody as a Cause of Panreactive Antibody Screening in Immunohematology
    Luzzi, J.
    Brito, C. A.
    Gimenez, N. T.
    Navarro-Xavier, R. A.
    Jesuino, D. B.
    TRANSFUSION, 2016, 56 : 139A - 139A
  • [9] A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia
    Chen, Yunfei
    Xu, Yanmei
    Li, Huiyuan
    Sun, Ting
    Cao, Xuan
    Wang, Yuhua
    Xue, Feng
    Liu, Wei
    Liu, Xiaofan
    Dong, Huan
    Fu, Rongfeng
    Dai, Xinyue
    Wang, Wentian
    Ma, Yueshen
    Song, Zhen
    Chi, Ying
    Ju, Mankai
    Gu, Wenjing
    Pei, Xiaolei
    Yang, Renchi
    Zhang, Lei
    NEW ENGLAND JOURNAL OF MEDICINE, 2024, 390 (23): : 2178 - 2190
  • [10] DARATUMUMAB Anti-CD38 Monoclonal Antibody, Treatment of Multiple Myeloma
    Richardson, P.
    Lokhorst, H.
    Palumbo, A.
    Nahi, H.
    Laubach, J.
    Gimsing, P.
    Lisby, S.
    Cakana, A.
    Brun, N. Constantin
    Plesner, T.
    DRUGS OF THE FUTURE, 2013, 38 (08) : 545 - 554