Comprehensive two-dimensional gas chromatography in metabolomics

被引：83
|
作者：
Almstetter, Martin F. [1 ]
Oefner, Peter J. [1 ]
Dettmer, Katja [1 ]
机构：
[1] Univ Regensburg, Inst Funct Genom, D-93053 Regensburg, Germany
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2012年 / 402卷 / 06期
关键词：
Metabolomics; Metabolite profiling; Metabolic fingerprinting; Comprehensive two-dimensional gas chromatography; FLIGHT-MASS-SPECTROMETRY; METHYLOBACTERIUM-EXTORQUENS AM1; GC-TOFMS DATA; PARALLEL FACTOR-ANALYSIS; X GC; SYSTEMS BIOLOGY; CHLAMYDOMONAS-REINHARDTII; AMINO-ACIDS; CHEMOMETRIC ANALYSIS; FUNCTIONAL GENOMICS;
D O I：
10.1007/s00216-011-5630-y
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC x GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC x GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.
引用
收藏
页码：1993 / 2013
页数：21
相关论文
共 50 条
  • [1] Comprehensive two-dimensional gas chromatography in metabolomics
    Martin F. Almstetter
    Peter J. Oefner
    Katja Dettmer
    [J]. Analytical and Bioanalytical Chemistry, 2012, 402 : 1993 - 2013
  • [2] Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics
    Keppler, Emily A. Higgins
    Jenkins, Carrie L.
    Davis, Trenton J.
    Bean, Heather D.
    [J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2018, 109 : 275 - 286
  • [3] Comprehensive Two-Dimensional Gas Chromatography Mass Spectrometry-Based Metabolomics
    Prodhan, Md Aminul Islam
    McClain, Craig
    Zhang, Xiang
    [J]. CANCER METABOLOMICS: METHODS AND APPLICATIONS, 2021, 1280 : 57 - 67
  • [4] Comprehensive Two-Dimensional Gas Chromatography
    Ryan, Danielle
    Marriott, Philip
    [J]. ADVANCES IN CHROMATOGRAPHY, VOL 46, 2008, 46 : 451 - 467
  • [5] Comprehensive two-dimensional gas chromatography
    Hinshaw, JV
    [J]. LC GC EUROPE, 2004, 17 (02) : 86 - +
  • [6] Comprehensive two-dimensional gas chromatography
    Hinshaw, JV
    [J]. LC GC NORTH AMERICA, 2004, 22 (01) : 32 - +
  • [7] Comprehensive two-dimensional gas chromatography
    Ryan, D
    Marriott, P
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 376 (03) : 295 - 297
  • [8] Comprehensive two-dimensional gas chromatography
    Danielle Ryan
    Philip Marriott
    [J]. Analytical and Bioanalytical Chemistry, 2003, 376 : 295 - 297
  • [9] Integrating comprehensive two-dimensional gas chromatography mass spectrometry and parallel two-dimensional liquid chromatography mass spectrometry for untargeted metabolomics
    Prodhan, Md Aminul Islam
    Shi, Biyun
    Song, Ming
    He, Liqing
    Yuan, Fang
    Yin, Xinmin
    Bohman, Patrick
    McClain, Craig J.
    Zhang, Xiang
    [J]. ANALYST, 2019, 144 (14) : 4331 - 4341
  • [10] Multidimensional and comprehensive - Two-dimensional gas chromatography
    Marriott, PJ
    Morrison, PD
    Shellie, RA
    Dunn, MS
    Sari, E
    Ryan, D
    [J]. LC GC EUROPE, 2003, 16 (12A) : 23 - 31
12345