Iodo-Cycloisomerization of Aryl(indol-3-yl)methane-Tethered Propargyl Alcohols to 3-lodocarbazoles via Selective 1,2-Alkyl Migration

被引：29

作者：

Yaragorla, Srinivasarao ^{[1
]}

Bag, Debojyoti ^{[1
]}

Dada, Ravikrishna ^{[1
]}

Jose, K. V. Jovan ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, PO Cent Univ, Hyderabad 500046, India

来源：

ACS OMEGA | 2018年 / 3卷 / 11期

关键词：

HOLE-TRANSPORTING MATERIALS; CROSS-COUPLING REACTIONS; CARBAZOLE SYNTHESIS; CATALYZED SYNTHESIS; ORGANIC-SYNTHESIS; FACILE SYNTHESIS; HOST MATERIALS; CYCLIZATION; ALKALOIDS; POLYCARBAZOLES;

D O I：

10.1021/acsomega.8b02393

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we disclose the first report on iodo-cycloisomerization of 1-(indol-3-yl)-1-arylbut-3-yn-2-ols to form 3-iodocarbazoles. The synthesis proceeds through a cascade 5-endo-spirocyclization, followed by selective 1,2-alkyl migration. This method governs the green synthesis principles such as open-flask reaction, AcOEt as the solvent, rt reaction with short time, use of iodine, and broad substrate scope with atom and step economy.

引用

页码：15024 / 15034

页数：11