Ionic complexes of biosynthetic poly(malic acid) and poly(glutamic acid) as prospective drug-delivery systems

被引：14
|
作者：
Portilla-Arias, Jose A. [1 ]
Garcia-Alvarez, Montserrat [1 ]
Martinez de Ilarduya, Antxon [1 ]
Munoz-Guerra, Sebastian [1 ]
机构：
[1] Univ Politecn Catalunya, Dept Engn Quim, ETSEIB, E-08028 Barcelona, Spain
来源：
MACROMOLECULAR BIOSCIENCE | 2007年 / 7卷 / 07期
关键词：
ionic polyglutamate complexes; ionic polymalate complexes; poly(beta-malic acid); poly(gamma-glutamic acid);
D O I：
10.1002/mabi.200700025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hydrolytic degradability and erythromycin release from stoichiometric ionic complexes of biotechnological poly(β,L-malic acid)s and poly(γ,D-glutamic acid)s with alkyltrimethylammonium surfactants were investigated. The influence of pH, temperature and antibiotic load on hydrolysis rate was examined. It was found that poly(malic acid) complexes degraded by a surface erosion mechanism at a higher rate than poly(glutamic acid) complexes, which eroded in bulk. Erythromycin was lodged in the paraffinic subphase of the complexes and upon aging it was delivered according to a sigmoidal profile that appeared to be independent on the antibiotic load. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：897 / 906
页数：10
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