Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus

被引：37
|
作者：
Antonini, G
Nemni, R
Giubilei, F
Gragnani, F
Ceschin, V
Morino, S
Bucci, E
Accornero, N
机构：
[1] Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy
[2] Univ Milan, Fdn Don C Gnocchi, Milan, Italy
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2003年 / 74卷 / 07期
关键词：
D O I：
10.1136/jnnp.74.7.998
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The cause of downbeat nystagmus (DBN) remains undiagnosed in about 40% of patients. This paper reports the presence of antiglutamic acid decarboxylase antibodies (GAD-Ab) in a patient with DBN. Antibodies against GABAergic neurons located in the vestibular complex may induce chemical denervation of the floccular neurons, which normally suppress the peripheral imbalance between vertical semicircular canal systems, thereby causing DBN. Testing for GAD-Ab may be indicated in DBN patients without an identifiable anatomical brain lesion.
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收藏
页码：998 / 999
页数：2
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