Microsatellite Instability and Loss of Heterozygosity in Cancer

被引：1
|
作者：
Didziapetriene, Janina [1 ]
Kanopiene, Daiva [1 ]
Valuckas, Konstantinas Povilas [1 ]
Uleckiene, Saule [1 ]
Atkocius, Vydmantas [1 ]
Micke, Ingrida [1 ]
Suziedelis, Kestutis [1 ]
机构：
[1] Vilnius Univ, Inst Oncol, Santariskiu 1, LT-08660 Vilnius, Lithuania
来源：
MEDICINA-LITHUANIA | 2011年 / 47卷 / 02期
关键词：
microsatellite instability; loss of heterozygosity; cancer; SQUAMOUS-CELL CARCINOMA; SHORTER CAG REPEAT; COLORECTAL-CANCER; BREAST-CANCER; CHROMOSOMAL INSTABILITY; GENETIC CLASSIFICATION; HIGH-FREQUENCY; LUNG-CANCER; AR GENE; HEAD;
D O I：
10.3390/medicina47020018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Literature review on genetic alterations (microsatellite instability and loss of heterozygosity) in different types of cancer is presented. Microsatellite instability and loss of heterozigosity are significant processes in carcinogenesis. The evaluation of microsatellite instability in cancer patients might be of clinical importance as a prognostic and predictive factor. The most of up-to-date data available are on microsatellite instability in colorectal cancer. For other types of cancer, the number of publications on microsatellite instability is rapidly increasing.
引用
收藏
页码：125 / 135
页数：11
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