High 28-day mortality in critically ill patients with sepsis and concomitant active cancer

被引:21
|
作者
Wang, Yong-gang [1 ]
Zhou, Jian-cang [1 ]
Wu, Kang-song [2 ]
机构
[1] Zhejiang Univ, Sch Med, Dept Crit Care Med, Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurocrit Care Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China
关键词
Sepsis; outcome; active cancer; intensive care unit; mortality; Simplified Acute Physiology Score II; SEPTIC SHOCK; DEFINITIONS; IL-10;
D O I
10.1177/0300060518789040
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective This study was performed to explore the characteristics and outcomes of patients with sepsis accompanied by active cancer who were admitted to the intensive care unit (ICU). Methods The baseline characteristics, infection profiles, and outcomes of patients with sepsis were retrospectively analyzed according to the presence of concomitant active cancer. The association between concomitant active cancer and 28-day mortality was explored. Results Of 23,956 patients with sepsis, 1574 (6.6%) had concomitant active cancer. The most common type was digestive (30.7%). The 28-day mortality ranged from 41.9% to 81.5%. Patients with active cancer had a significantly higher Simplified Acute Physiology Score II and significantly shorter length of ICU stay. Respiratory (32.9%), genitourinary (31.0%), and bloodstream (17.0%) infections were most common. Escherichia coli was the most frequent gram-negative pathogenic bacteria. The 28-day mortality rate was significantly higher in patients with than without active cancer. Concomitant active cancer was associated with increased 28-day mortality in patients with sepsis. Hematological malignancy was associated with a significantly higher risk of death than solid tumors. Conclusions Concomitant active cancer was associated with higher 28-day mortality in patients with sepsis requiring ICU admission. Hematological malignancy was associated with a higher risk of death than solid tumors.
引用
收藏
页码:5030 / 5039
页数:10
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