GPVI and integrin αIIβ3 signaling in platelets

被引：305

作者：

Watson, SP ^{[1
]}

Auger, JM ^{[1
]}

McCarty, OJT ^{[1
]}

Pearce, AC ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Ctr Cardiovasc Sci, Div Med Sci,Inst Biomed Res, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2005年 / 3卷 / 08期

基金：

英国惠康基金;

关键词：

collagen; GPVL integrin; Src kinases; Syk; tyrosine kinases;

D O I：

10.1111/j.1538-7836.2005.01429.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alpha IIb beta 3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase C gamma 2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.

引用

页码：1752 / 1762

页数：11

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