Expression of cyclooxygenase-2 in canine nasal carcinomas

被引：23
|
作者：
Impellizeri, Joseph A. [1 ]
Esplin, D. Glen [2 ]
机构：
[1] PLLC, Vet Oncol Serv, Hopewell Jct, NY 12533 USA
[2] ARUP Labs, Salt Lake City, UT 84108 USA
来源：
VETERINARY JOURNAL | 2008年 / 176卷 / 03期
关键词：
cyclooxygenase-2; nasal carcinomas; COX-2; immunohistochemistry; nasal cancer;
D O I：
10.1016/j.tvjl.2007.03.022
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Cyclooxygenase(COX)-2 expression was evaluated in 24 paraffin-embedded canine nasal carcinoma tissue samples by immunohistochemistry. Several different tumor types were represented, including carcinomas, adenocarcinomas and squamous cell carcinomas. COX-2 expression was identified in 17/24 cases (71%). The proportion of positive cells expressing COX-2 ranged from 10 to 95% and COX-2 expression was predominantly localized in the cytoplasm. Treatment with a COX-2 inhibitor should be investigated, along with the utilization of COX-2 expression as a prognostic marker. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：408 / 410
页数：3
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