"I do not feel my hand where I see it": causal mapping of visuo-proprioceptive integration network in a surgical glioma patient

被引：10

作者：

Mandonnet, Emmanuel ^{[1
,2
,3
]}

Margulies, Daniel ^{[3
]}

Stengel, Chloe ^{[3
]}

Dali, Melissa ^{[1
]}

Rheault, Francois ^{[4
]}

Toba, Monica N. ^{[3
,5
,6
]}

Bonnetblanc, Francois ^{[7
]}

Valero-Cabre, Antoni ^{[3
]}

机构：

[1] Lariboisiere Hosp, AP HP, Dept Neurosurg, 2 Rue Ambroise Pare, F-75010 Paris, France

[2] Univ Paris 07, Paris, France

[3] ICM, Frontlab, Paris, France

[4] Univ Sherbrook, Fac Sci, Dept Comp Sci, Sherbrook Connect Imaging Lab, Sherbrooke, PQ, Canada

[5] Univ Hosp Amiens, Lab Funct Neurosci, EA 4559, Amiens, France

[6] Univ Picardy Jules Verne, Amiens, France

[7] Univ Montpellier, CAMIN Team, LIRMM, INRIA, Montpellier, France

来源：

ACTA NEUROCHIRURGICA | 2020年 / 162卷 / 08期

关键词：

Visuo-proprioceptive integration; Awake surgery; Functional connectivity; Structural connectivity; PARIETAL LOBE; REPRESENTATIONS; TRACTOGRAPHY; STIMULATION;

D O I：

10.1007/s00701-020-04399-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A recent tasked-based fMRI study unveiled a network of areas implicated in the process of visuo-proprioceptive integration of the right hand. In this study, we report a case of a patient operated on in awake conditions for a glioblastoma of the left superior parietal lobule. When stimulating a white matter site in the anterior wall of the cavity, the patient spontaneously reported a discrepancy between the visual and proprioceptive perceptions of her right hand. Using several multimodal approaches (axono-cortical evoked potentials, tractography, resting-state functional connectivity), we demonstrated converging support for the hypothesis that tumor-induced plasticity redistributed the left-lateralized network of right-hand visuo-proprioceptive integration towards its right-lateralized homolog.

引用

页码：1949 / 1955

页数：7