Synthesis of novel dihydrooxazine and oxazoline based sugar hybrids from sugar azides

被引：6
|
作者：
Kurhade, Suresh E. [1 ,2 ]
Ravula, Sudhir [1 ]
Siddaiah, V. [2 ]
Bhuniya, Debnath [1 ]
Reddy, D. Srinivasa [1 ,3 ]
机构：
[1] Advinus Therapeut Ltd, Discovery Chem, Pune 411057, Maharashtra, India
[2] Andhra Univ, Dept Organ Chem, Visakhapatnam 530003, Andhra Pradesh, India
[3] Natl Chem Lab CSIR, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 33期
关键词：
Sugar hybrids; Oxazoline; Dihydrooxazine; Hydroxy azide; Sugar azide; Glycoconjugate; BIOLOGICAL EVALUATION; DESIGN; ANALOGS;
D O I：
10.1016/j.tetlet.2011.06.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient one-step method for the synthesis of novel dihydrooxazine and oxazoline based sugar hybrids is reported starting from the readily accessible sugar azides and aldehydes. We have used Aube's protocol to achieve this transformation. The resulting glycoconjugates could be used to increase the diversity on the sugar backbone and may find applications as potential glycomimetics and in drug discovery. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4313 / 4315
页数：3
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