Recent Progress Towards Synthesis of the Indolizidine Alkaloid 195B

被引：14

作者：

Ziarani, Ghodsi Mohammadi ^{[1
]}

Mohajer, Fatemeh ^{[1
]}

Kheilkordi, Zohreh ^{[1
]}

机构：

[1] Alzahra Univ, Dept Chem, Tehran, Iran

来源：

CURRENT ORGANIC SYNTHESIS | 2020年 / 17卷 / 02期

关键词：

Natural products; alkaloids; aromatic groups; indolizidine; 195B; biologically active compounds; poisonous frog; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CATALYZED ALLYLIC AMINATIONS; CROSS-COUPLING REACTIONS; ASYMMETRIC-SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; 2,5-DISUBSTITUTED PYRROLIDINES; POISON FROGS; STRATEGY; SYSTEM; RING;

D O I：

10.2174/1570179417666200124104010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Background: Natural products have been received attention due to their importance in human life as those are biologically active. In this review, there are some reports through different methods related to the synthesis of the indolizidine 195B which was extracted from poisonous frog; however, due to respect nature, the synthesis of natural compounds such as indolizidine has been attracted much attention among scientists and researchers. Objective: This review discloses the procedures and methods to provide indolizidine 195B from 1989 to 2018 due to their importance as a natural product. Conclusion: There are several methods to give rise to the indolizidine 195B as a natural product that is highly active from the biological perspective in pharmaceutical chemistry. In summary, many protocols for the preparations of indolizidine 195B from various substrates, several reagents, and conditions have been reported from different aromatic and aliphatic.

引用

页码：82 / 90

页数：9

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