AlCl3-PROMOTED CYCLIZATION OF β-KETO DERIVATIVES WITH IN SITU GENERATED ENAMINES UNDER SOLVENT-FREE HIGH SPEED BALL MILLING: AN EFFICIENT ONE-POT ACCESS TO POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES

被引：3
|
作者：
Zeng, Ji-Chao [1 ]
Yu, Fei [1 ]
Asiri, Abdullah M. [2 ]
Marwani, Hadi M. [2 ]
Zhang, Ze [1 ]
机构：
[1] Anhui Polytech Univ, Sch Biol & Chem Engn, Wuhu 241000, Peoples R China
[2] King Abdulaziz Univ, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia
来源：
HETEROCYCLES | 2017年 / 94卷 / 11期
关键词：
1,4-Dihydropyridine; High Speed Ball Milling (HSBM); Solvent-Free Reaction; Cyclization Reaction; Enamine; SUBSTITUTED 1,4-DIHYDROPYRIDINES; POLYHYDROQUINOLINE DERIVATIVES; 1,3-DICARBONYL COMPOUNDS; 3-COMPONENT CYCLIZATION; ORGANIC-SYNTHESIS; DIHYDROPYRIDINES; CHEMISTRY; ALDEHYDES; ACID; TETRAHYDROPYRIDINES;
D O I：
10.3987/COM-17-13801
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Under high speed ball milling (HSBM), a simple method for efficient synthesis of structurally diverse polysubstituted 1,4-dihydropyridines is developed via AlCl3-promoted Robinson-like cyclization of beta-keto derivatives with in situ generated enamines. This one-pot protocol exhibits the advantages of high chemoselectivity, short reaction time, good functional group tolerance, mild reaction condition and easy work-up.
引用
收藏
页码：2054 / 2064
页数：11
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