Inhibitory Effects of Cultivated Wild Ginseng on the Differentiation of 3T3-L1 Pre-adipocytes

被引：4

作者：

Mollah, Mohammad Lalmoddin ^{[2
]}

Cheon, Yong-Pil ^{[2
]}

In, Jun-Gyo ^{[3
]}

Yang, Deok-Chun ^{[4
,5
]}

Kim, Young-Chul ^{[6
]}

Song, Jae-Chan ^{[1
]}

Kim, Kil-Soo ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Sci, Taegu 702701, South Korea

[2] Sungshin Womens Univ, Coll Nat Sci, Seoul 136742, South Korea

[3] Korea Ginseng Corp, Nat Resources Res Inst, Taejon 305805, South Korea

[4] Kyung Hee Univ, Korean Ginseng Ctr Most Valuable Prod, Yongin 446701, South Korea

[5] Kyung Hee Univ, Ginseng Genet Resource Bank, Yongin 446701, South Korea

[6] Keimyung Univ, Coll Nat Sci, Taegu 704701, South Korea

来源：

JOURNAL OF GINSENG RESEARCH | 2011年 / 35卷 / 01期

关键词：

Panax ginseng; Cultivated wild ginseng; 3T3-L1; cells; Adipocyte differentiation; Adipogenesis; Cell cycle arrest; PPAR-GAMMA; INSULIN-RESISTANCE; OBESITY; ADIPOGENESIS; EXTRACT; CELLS;

D O I：

10.5142/jgr.2011.35.1.045

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 pre-adipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)gamma and CCAAT/enhancer-binding protein alpha mRNA. It also inhibited the expression of PPAR gamma and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-G, phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.

引用

页码：45 / 51

页数：7

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