Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age

PURPOSE: The purpose of this study was to investigate whether corneas from donors Z80 years old are suitable for Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Retrospective, comparative, interventional case series. METHODS: Records of 1,765 consecutive DMEKs were reviewed and matched with corresponding donor tissue data. Older donors (>= 80 years of age) were compared to younger donors ( < 80 years). Outcome measurements in DMEK recipients included best spectacle-corrected visual acuity (BSCVA), endothelial cell density (ECD), central corneal thickness (CCT) at 3 and 6 months and at 1, 2, and 3 years' follow-up and re-bubbling rates. RESULTS: Of 1,748 DMEKs, 284 (16.2%) were performed with older donor lamellae (mean donor age, 83.96 +/- 3.19 years; range, 80-94 years) and 1,464 (83.7%) with younger donor tissue (mean donor age, 65.27 +/- 9.57 years; range, 17-79). BSCVA results were comparable for all postoperative time points. CCT results for younger donors were more favorable in the early postoperative course (P < 0.001 at 6 months; and P < 0.001 at 1 year), whereas mid-term results were comparable in both groups. ECD values were significantly higher in donors < 80 years of age preoperatively and during the first 2 postoperative years (P <= 0.024). Overall re-bubbling rates were comparable in both groups. CONCLUSIONS: Older donors, >= 80 to 94 years of age, seem to produce comparable mid-term functional results following DMEK surgery compared to younger donors. The use of corneas from donors aged >= 80 for DMEK surgery may therefore be a promising approach to counteract global donor shortage. ((C) 2019 Elsevier Inc. All rights reserved.)