Caenorhabditis elegans in high-throughput screens for anti-infective compounds

被引：30
|
作者：
Peterson, Nicholas D. [1 ]
Pukkila-Worley, Read [1 ]
机构：
[1] Univ Massachusetts, Med Sch, Div Infect Dis & Immunol, Program Innate Immun, Worcester, MA 01655 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2018年 / 54卷
基金：
美国国家卫生研究院;
关键词：
INHIBITS HYPHAL MORPHOGENESIS; ANIMAL INFECTION MODEL; TOLL-LIKE RECEPTOR; PSEUDOMONAS-AERUGINOSA; C; ELEGANS; INNATE IMMUNITY; CANDIDA-ALBICANS; HOST-DEFENSE; VIRULENCE; PATHOGENESIS;
D O I：
10.1016/j.coi.2018.06.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
New classes of antimicrobials that are effective therapies for infections with multi-drug resistant pathogens are urgently needed. The nematode Caenorhabditis elegans has been incorporated into small molecule screening platforms to identify anti-infective compounds that provide protection of a host during infection. The use of a live animal in these screening systems offers several advantages, including the ability to identify molecules that boost innate immune responses in a manner advantageous to host survival and compounds that disrupt bacterial virulence mechanisms. In addition, new classes of antimicrobials that target the pathogen have been uncovered, as well as interesting chemical probes that can be used to dissect new mechanisms of host-pathogen interactions.
引用
收藏
页码：59 / 65
页数：7
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