The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

被引：188
|
作者：
Cowman, Alan F. [1 ,2 ]
Tonkin, Christopher J. [1 ,2 ]
Tham, Wai-Hong [1 ,2 ]
Duraisingh, Manoj T. [3 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, 1G Royal Parade, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia
[3] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA
来源：
CELL HOST & MICROBE | 2017年 / 22卷 / 02期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
PLASMODIUM-FALCIPARUM INVASION; HOST-CELL INVASION; DEPENDENT PROTEIN-KINASE; RED-BLOOD-CELL; MEROZOITE SURFACE PROTEIN; MEMBRANE ANTIGEN 1; CLASS-XIV MYOSIN; TOXOPLASMA-GONDII; APICOMPLEXAN PARASITES; RECEPTOR;
D O I：
10.1016/j.chom.2017.07.003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.
引用
收藏
页码：232 / 245
页数：14
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