Automated synthesis of [18F]gefitinib on a modular system

被引：17
|
作者：
Lappchen, Tilman [1 ]
Vlaming, Maria L. H. [2 ]
Custers, Erica [1 ]
Lub, Johan [1 ]
Sio, Charles F. [1 ]
DeGroot, Jeroen [2 ]
Steinbach, Oliver C. [1 ]
机构：
[1] Philips Res Europe, Dept Biomol Engn, NL-5656 AE Eindhoven, Netherlands
[2] TNO, NL-3704 HE Zeist, Netherlands
来源：
APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 01期
关键词：
F-18]gefitinib; Modular system; Automated synthesis; PET tracer; Imaging of drug transporters; GROWTH-FACTOR RECEPTOR; P-GLYCOPROTEIN; TUMORS; BRAIN;
D O I：
10.1016/j.apradiso.2011.09.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In recent years, [F-18]gefitinib PET has successfully been employed for a number of applications ranging from oncology to in vivo studies of drug transporter proteins. We here report a reliable, automated procedure for routine synthesis of this radiotracer on an Eckert and Ziegler modular system. The 3-step radiosynthesis followed by preparative HPLC-purification provided [F-18]gefitinib in 17.2 +/- 3.3% (n=22) overall decay-corrected radiochemical yield with radiochemical purity > 99% in a total synthesis time of about 2.5 h. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：205 / 209
页数：5
相关论文
共 50 条
  • [1] FULLY AUTOMATED PREPARATION OF [18F]FPyBrA IN A MODULAR SYNTHESIS SYSTEM
    von Guggenberg, E.
    Sader, J.
    Wilson, J.
    Shahhosseini, S.
    Koslowsky, I.
    Wuest, F.
    Mercer, J.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2009, 52 : S296 - S296
  • [2] Automated synthesis of [18F]Raltegravir through [18F]fluorobenzylamine
    Blecha, Joseph
    Neumann, Kiel
    VanBrocklin, Henry
    JOURNAL OF NUCLEAR MEDICINE, 2018, 59
  • [3] Production of [18F]gefitinib on an Eckert & Ziegler Modular-Lab
    Lappchen, Tilman
    Vlaming, Maria L. H.
    Custers, Erica
    Lub, Johan
    Sio, Charles F.
    DeGroot, Jeroen
    Steinbach, Oliver C.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2011, 54 : S428 - S428
  • [4] Automated synthesis of [18F]FMISO on Synthera®
    Blom, E.
    Fedorova, O.
    Koziorowski, J.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 : S408 - S408
  • [5] AUTOMATED SYNTHESIS OF [18F]FLUOROMETHYLCHOLINE (FCH)
    Morandeau, L. M.
    DeGrado, T. R.
    McKinney, C. J.
    Chan, S. Y.
    Meyrick, D. P.
    Jones, C. G.
    Price, R. I.
    Lenzo, N.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2005, 48 : S219 - S219
  • [6] THE CONSTRUCTION OF AN AUTOMATED SYSTEM FOR [18F] FDG SYNTHESIS DEDICATED TO RESEARCH
    Craciun, L.
    Cimpeanu, C.
    Constantinescu, O.
    Dudu, D.
    Ionescu, C.
    Negoita, N.
    Racolta, P. M.
    ROMANIAN JOURNAL OF PHYSICS, 2009, 54 (3-4): : 341 - 347
  • [7] Automated synthesis of 18F analogue of paclitaxel (PAC):: [18F]Paclitaxel (FPAC)
    Kalen, Joseph D.
    Hirsch, Jerry I.
    Kurdziel, Karen A.
    Eckelman, William C.
    Kiesewetter, Dale O.
    APPLIED RADIATION AND ISOTOPES, 2007, 65 (06) : 696 - 700
  • [8] Fully automated synthesis of [18F]fluorodihydrotestosterone([18F]FDHT) using the FlexLab module
    Ackermann, Uwe
    Lewis, Jason S.
    Young, Kenneth
    Morris, Michael J.
    Weickhardt, Andrew
    Davis, Ian D.
    Scott, Andrew M.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2016, 59 (10): : 424 - 428
  • [9] Fully automated synthesis of [18F]fluoromisonidazole using a conventional [18F]FDG module
    Oh, SJ
    Chi, DY
    Mosdzianowski, C
    Kim, JY
    Gil, HS
    Kang, SH
    Ryu, JS
    Moon, DH
    NUCLEAR MEDICINE AND BIOLOGY, 2005, 32 (08) : 899 - 905
  • [10] Automated synthesis of [18F]FMISO on IBA Synthera®
    Blom, Elisabeth
    Koziorowski, Jacek
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2014, 299 (01) : 265 - 270
12345