pH-Responsive self-duplex of PyA-substituted oligodeoxyadenylate in graphene oxide solution as a molecular switch

被引：17

作者：

Yi, Jeong Wu ^{[1
]}

Park, Jaesung ^{[2
]}

Kim, Kwang S. ^{[2
]}

Kim, Byeang Hyean ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Div IBB, Dept Chem, Lab Modified Nucle Acid Syst, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, BK Sch Mol Sci, Ctr Superfunct Mat, Dept Chem, Pohang 790784, South Korea

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 21期

关键词：

DNA NANOMACHINE; QUENCHER-FREE; TRANSITION; FLUORESCENCE; TRIPLEX; SYSTEM; MOTIF;

D O I：

10.1039/c1ob06037f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we demonstrated a highly discriminated and reliable molecular switch based on the interaction between the self-duplex of (Py)A-substituted oligodeoxyadenylate and graphene oxide in aqueous solution. This system showed a clear on/off state through the association and dissociation of (Py)A-modified oligodeoxynucleotide with graphene oxide in manipulated pH conditions, high amplitude efficiency for at least 50 cycles, and rapid response within seconds. Our molecular switch system has high reproducibility and simple operation by using pH stimulus.

引用

页码：7434 / 7438

页数：5

共 4 条

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