How to diagnose and treat post-stroke seizures and epilepsy

被引：58

作者：

Zelano, Johan ^{[1
,2
]}

Holtkamp, Martin ^{[3
]}

Agarwal, Nivedita ^{[4
]}

Lattanzi, Simona ^{[5
]}

Trinka, Eugen ^{[6
,7
,8
]}

Brigo, Francesco ^{[9
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden

[2] Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden

[3] Charite Univ Med Berlin, Dept Neurol, Epilepsy Ctr Berlin Brandenburg, Berlin, Germany

[4] Hosp Rovereto, Radiol Unit, Trento, Italy

[5] Marche Polytech Univ, Dept Expt & Clin Med, Neurol Clin, Ancona, Italy

[6] Paracelsus Med Univ, Affiliated Partner ERN EpiCARE, Christian Doppler Klin, Dept Neurol, Salzburg, Austria

[7] Ctr Cognit Neurosci, Salzburg, Austria

[8] Univ Hlth Sci Med Informat & Technol, Publ Hlth Hlth Serv Res & HTA, Hall I T, Austria

[9] Franz Tappeiner Hosp, Dept Neurol, Merano, Italy

来源：

EPILEPTIC DISORDERS | 2020年 / 22卷 / 03期

关键词：

intracerebral haemorrhage; ischaemic stroke; post-stroke epilepsy; post-stroke seizures; treatment; ACUTE SYMPTOMATIC SEIZURES; ISCHEMIC-STROKE; ANTIEPILEPTIC DRUGS; STATUS EPILEPTICUS; PREDICTION MODEL; RISK; CARBAMAZEPINE; LEVETIRACETAM; EEG; LAMOTRIGINE;

D O I：

10.1684/epd.2020.1159

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stroke is one of the commonest causes of seizures and epilepsy, mainly among the elderly and adults. This seminar paper aims to provide an updated overview of post-stroke seizures and post-stroke epilepsy (PSE) and offers clinical guidance to anyone involved in the treatment of patients with seizures and stroke. The distinction between acute symptomatic seizures occurring within seven days from stroke (early seizures) and unprovoked seizures occurring afterwards (late seizures) is crucial regarding their different risks of recurrence. Asingle late post-stroke seizure carries a risk of recurrence as high as 71.5% (95% confidence interval: 59.7-81.9) at ten years and is diagnostic of PSE. Several clinical and stroke characteristics are associated with increased risk of post-stroke seizures and PSE. So far, there is no evidence supporting the administration of antiepileptic drugs as primary prevention, and evidence regarding their use in PSE is scarce.

引用

页码：252 / 263

页数：12

共 50 条

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