Medicinal chemistry progression of antimalarial hits from phenotypic whole cell screening of SoftFocus libraries

被引：4
|
作者：
Cheuka, Peter M. [1 ,2 ]
Mayoka, Godfrey [1 ,3 ]
Okombo, John [4 ]
Chibale, Kelly [1 ,5 ,6 ,7 ]
机构：
[1] Univ Cape Town, Dept Chem, Cape Town, South Africa
[2] Univ Zambia, Dept Chem, Lusaka, Zambia
[3] Jomo Kenyatta Univ Agr & Technol, Sch Pharm, Dept Pharmacol & Pharmacognosy, Nairobi, Kenya
[4] Columbia Univ, Dept Microbiol & Immunol, New York, NY USA
[5] Univ Cape Town, Drug Discovery & Dev Ctr H3D, Cape Town, South Africa
[6] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa
[7] Univ Cape Town, South African Med Res Council, Drug Discovery & Dev Res Unit, Cape Town, South Africa
来源：
MEDICINAL CHEMISTRY APPROACHES TO MALARIA AND OTHER TROPICAL DISEASES | 2019年 / 53卷
关键词：
ANTIPLASMODIAL IMIDAZOPYRIDAZINE HITS; HUMAN MALARIA PARASITE; PLASMODIUM-FALCIPARUM; PROTEIN-KINASE; SUBSTITUTED IMIDAZOPYRIDAZINES; POTENT INHIBITORS; OPTIMIZATION; IDENTIFICATION; DERIVATIVES; SOLUBILITY;
D O I：
10.1016/bs.armc.2019.04.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：25 / 71
页数：47
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