Risk factors of bronchial hyperresponsiveness in children with wheezing-associated respiratory infection

被引:8
|
作者
Futrakul, S
Deerojanawong, J
Prapphal, N
机构
[1] Monash Med Ctr, Newborn Serv, Melbourne, Vic 3168, Australia
[2] King Chulalongkorn Mem Hosp, Dept Pediat, Pulm Unit, Bangkok, Thailand
关键词
risk factor; bronchial hyperresponsiveness; wheezing-associated respiratory infection; pulmonary function test;
D O I
10.1002/ppul.20228
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The objectives of this study were to identify possible risk factors of bronchial hype responsiveness (BHR) in children up to 5 years of age with wheezing-associated respiratory infection (WARI), and to study the prevalence of BHR. Children up to 5 years of age with WARI were enrolled in the study The parents or caregivers of children were asked about their demographic data and clinical histories. Physical examination and clinical score assessment were performed. Pulmonary function tests, i.e., tidal breathing flow volume (TBFV), were performed to measure tidal breathing parameters before and after salbutamol nebulization. If volume at peak tidal expiratory flow/expiratory tidal volume and time to peak expiratory flow/total expiratory time increased >= 20%, or tidal expiratory flow at 25% of tidal volume/peak tidal expiratory flow increased >= 20% after nebulization therapy, BHR was diagnosed. The number in the positive BHR group was used to calculate the prevalence of BHR, and clinical features were compared with those of the negative BHR group. Categorical data were analyzed for statistical significance (P < 0.05) by chi-square test or Fisher's exact test, or Student's t-test, as appropriate. Odds ratios (ORs) and 95% confidence intervals (Cls) were calculated for those with statistical significance. One hundred and six wheezing children underwent pulmonary function tests before and after salbutamol nebulization. With the aforementioned criteria, 41 cases (38.7%) were diagnosed with BHR. History of reactive airway disease, (OR, 6.31; 95% Cl, 1.68-25), maternal history of asthma (OR, 3.45; 95% Cl, 1.34-9), breastfeeding less than 3 months (OR, 3.18; 95% Cl, 1.26-8.12), and passive smoking (OR, 3; 95% Cl, 1.15-7.62) were significant risk factors of BHR. The eosinophil count was significantly higher in the BHR (+) group particularly, in children 1-5 years of age (P <= 0.01). Patchy infiltrates were more commonly found in patients with negative BHR but not statistically significant. In conclusion, a history of reactive airway disease, maternal history, breastfeeding less than 3 months, and passive smoking were significant risk factors for BHR. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码:81 / 87
页数:7
相关论文
共 50 条
  • [1] Occasional wheezing in children is not always associated with bronchial hyperresponsiveness (BHR).
    Roizin, H
    Reshef, A
    Benzaray, S
    Shiner, RJ
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1996, 97 (01) : 533 - 533
  • [2] Bronchial hyperresponsiveness in children with allergic rhinitis and the associated risk factors
    Karaatmaca, Betul
    Cetinkaya, Pinar Gur
    Esenboga, Saliha
    Ozer, Murat
    Soyer, Ozge
    Karabulut, Erdem
    Sekerel, Bulent Enis
    Sahiner, Umit Murat
    ALLERGY, 2019, 74 (08) : 1563 - 1565
  • [3] FACTORS ASSOCIATED WITH BRONCHIAL HYPERRESPONSIVENESS IN AUSTRALIAN ADULTS AND CHILDREN
    PEAT, JK
    SALOME, CM
    WOOLCOCK, AJ
    EUROPEAN RESPIRATORY JOURNAL, 1992, 5 (08) : 921 - 929
  • [4] Risk factors for bronchial hyperresponsiveness in children with allergic rhinitis
    Kim, J
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) : S74 - S74
  • [5] Recurrent wheezing in infants and young children and bronchial hyperresponsiveness - A perspective
    Hopp, RJ
    CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2003, 24 (01) : 7 - 17
  • [6] UNUSUALLY HIGH-INCIDENCE OF WHEEZING-ASSOCIATED RESPIRATORY ILLNESS IN AN ISRAELI TOWN
    WILENSKY, DS
    SLATER, PE
    BARHAIM, Y
    TROPICAL AND GEOGRAPHICAL MEDICINE, 1986, 38 (02): : 110 - 112
  • [7] Risk factors for wheezing in children - The role of respiratory viruses
    Arruda, L. Karla
    Ferriani, Virginia P. L.
    Silva, Jorgete
    Camara, Ataide A.
    Arruda, Eurico
    ALLERGY & CLINICAL IMMUNOLOGY INTERNATIONAL-JOURNAL OF THE WORLD ALLERGY ORGANIZATION, 2007, 19 (05): : 185 - 191
  • [8] Wheezing due to rhinovirus infection in infancy:: Bronchial hyperresponsiveness at school age
    Kotaniemi-Syrjanen, Anne
    Reijonen, Tiina M.
    Korhonen, Kaj
    Waris, Matti
    Vainionpaa, Raija
    Korppi, Matti
    PEDIATRICS INTERNATIONAL, 2008, 50 (04) : 506 - 510
  • [9] CHILDREN WITH HIGH RISK OF SEVERE RESPIRATORY SYNCYTIAL VIRUS INFECTION: PREVALENCE AND RISK FACTORS FOR RECURRENT WHEEZING
    Ribeiro dos Santos Simoes, Maria Cristina
    Matsunaga, Natasha Yumi
    Goncalves De Oliveira Ribeiro, Maria Angela
    Ribeiro, Jose Dirceu
    Morcillo, Andre Moreno
    Dalbo Contrera Toro, Adyleia Aparecida
    PEDIATRIC PULMONOLOGY, 2016, 51 : S22 - S22
  • [10] Association between Atopy and Bronchial Hyperresponsiveness in Preschool children with Recurrent Wheezing
    Lee, J.
    Suh, D.
    Koh, Y.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (02) : AB3 - AB3