Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease

被引：25
|
作者：
Jadideslam, Golamreza [1 ,2 ,3 ,4 ]
Ansarin, Khalil [2 ]
Sakhinia, Ebrahim [2 ]
Babaloo, Zohreh [2 ]
Abhari, Alireza [5 ,6 ]
Alipour, Shahriar [2 ]
Farhadi, Jafar [2 ]
Shirvani, Sam S. [2 ]
Ghojazadeh, Morteza [7 ]
Khabbazi, Alireza [2 ]
机构：
[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Mol Med, Tabriz, Iran
[2] Tabriz Univ Med Sci, Dept Internal Med, Connect Tissue Dis Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Biomed Inst, Mol Med Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Fac Med, Student Res Comm, Tabriz, Iran
[5] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran
[6] Tabriz Univ Med Sci, Fac Med, Div Clin Biochem, Clin Lab, Tabriz, Iran
[7] Tabriz Univ Med Sci, RDCC, Tabriz, Iran
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 16期
关键词：
Behcet's disease; biomarker; miR-146b; miR-21; miR-326; miRNA; uveitis; INTERFERON-GAMMA; CELLS; MICRORNA-21; AUTOIMMUNE; TH17;
D O I：
10.2217/bmm-2019-0098
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.
引用
收藏
页码：1339 / 1348
页数：10
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