Atypical Small Acinar Proliferation and High-grade Prostatic Intraepithelial Neoplasia in the Era of Multiparametric Magnetic Resonance Imaging: A Contemporary Review
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作者:
Manning, Todd G.
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Manning, Todd G.
Cheung, Ernest
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Cheung, Ernest
Perera, Marlon
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Perera, Marlon
Christidis, Daniel
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Christidis, Daniel
O'Brien, Jonathan S.
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
O'Brien, Jonathan S.
Mitchell, Catherine
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Mitchell, Catherine
Bolton, Damien M.
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Bolton, Damien M.
Lawrentschuk, Nathan
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机构:Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
Lawrentschuk, Nathan
机构:
[1] Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic, Australia
[2] YURO, Melbourne, Vic, Australia
[3] Peter MacCallum Canc Ctr, Dept Pathol, Melbourne, Vic, Australia
[4] Peter MacCallum Canc Ctr, Dept Surg Oncol, Melbourne, Vic, Australia
[5] Olivia Newton John Canc Res Inst, Melbourne, Vic, Australia
Multiparametric magnetic resonance imaging (mpMRI) has added to the armamentarium for the diagnosis and surveillance for organ-confined prostate cancer. Atypical small acinar proliferation and high-grade prostatic intraepithelial neoplasia (HGPIN) are premalignant prostatic lesions. The management of such lesions remains contentious, and the addition of mpMRI introduces further uncertainty, given its ability to pick up indolent lesions and its use in targeted biopsy. We aimed to perform a comprehensive review of current evidence regarding atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, and mpMRI to ascertain a consensus for a current management algorithm. (C) 2017 Published by Elsevier Inc.